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Article

Single-chain antibody against the common epitope of mutant p53: isolation and intracytosolic expression in mammalian cells.

Journal of immunological methods - 1 Dec 2001

Govorko D, Cohen G, Solomon B

Abstract excerpt

The peptide epitope FRHSVV is cryptic in wild-type p53 and is exposed in many types of mutant p53 molecules isolated from various tumors. Mutant p53 marked by this epitope abrogates a tumor-suppressor function of wild-type p53 and possibly contributes to the transforming potential of other oncogenic processes. We report here the construction of a single-chain scFv antibody gene library derived from the mRNA of a...

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Identifiers

PMID: 11684134
DOI: 10.1016/s0022-1759(01)00495-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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