Article
Resistance to genotoxic stresses in Arctica islandica, the longest living noncolonial animal: is extreme longevity associated with a multistress resistance phenotype?
The journals of gerontology. Series A, Biological sciences and medical sciences - 1 May 2013
Ungvari Zoltan, Sosnowska Danuta, Mason Jeffrey B, Gruber Heike, Lee Star W, Schwartz Tonia S, Brown Marishka K, Storm Nadia J, Fortney Kristen, Sowa Jessica, Byrne Alexandra B, Kurz Tino, Levy Erik, Sonntag William E, Austad Steven N, Csiszar Anna, Ridgway Iain
Abstract excerpt
Bivalve molluscs are newly discovered models of successful aging. Here, we test the hypothesis that extremely long-lived bivalves are not uniquely resistant to oxidative stressors (eg, tert-butyl hydroperoxide, as demonstrated in previous studies) but exhibit a multistress resistance phenotype. We contrasted resistance (in terms of organismal mortality) to genotoxic stresses (including topoisomerase inhibitors,...
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