Identification and Characterisation of a Platelet GPIb/V/IX‐like Complex on Human Breast Cancers: Implications for the Metastatic Process

Abstract excerpt

The glycoprotein (GP) Ib /V/IX receptor complex is an important adhesion molecule, originally thought to be unique to the megakaryocytic lineage. Recent evidence now indicates that GPIb /V/IX may be more widely expressed. In this study we report the presence of all subunits of the complex on four breast cancer cell lines, and 51 / 80 primary breast tumours. The surface expression of GPIb /V/IX was confirmed by...

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