Article
Three new cases of dysfibrinogenemia: Poissy III, Saint-Germain I and Tahiti.
Thrombosis research - 1 Aug 2001
Mathonnet F, Peltier J Y, Roda L, de Raucourt E, D'Hailly F, Tetegan M, Catherine N, Vinatier I, de Mazancourt P
Abstract excerpt
In order to identify unknown mutations, the FAMA method was used to rapidly screen the fibrinogen chain genes in individuals with dysfibrinogenemias. Chemical cleavage at mismatches on heteroduplexes DNA end-labeled with strand-specific fluorescent dyes reliably detects sequence changes in DNA fragments of up to 1.5 kb and locates them precisely. This method was successfully used for the detection of three new...
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