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Article

Epstein-Barr virus transactivates the human endogenous retrovirus HERV-K18 that encodes a superantigen.

Immunity - 1 Oct 2001

Sutkowski N, Conrad B, Thorley-Lawson D A, Huber B T

Abstract excerpt

Superantigens (SAgs) are proteins produced by pathogenic microbes to elicit potent, antigen-independent T cell responses that are believed to enhance the microbes' pathogenicity. Here we show that the human lymphotropic herpesvirus Epstein-Barr virus (EBV) transcriptionally activates the env gene of an endogenous retrovirus, HERV-K18, that possesses SAg activity. SAg activity was demonstrated by MHC class II...

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Share to Burkitt Lymphoma
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Viral

Share to Gene Products, env

Share to Herpesvirus 4, Human

Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

Identifiers

PMID: 11672540
DOI: 10.1016/s1074-7613(01)00210-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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