Bioinformatics and Mass Spectrometry for Microorganism Identification:  Proteome-Wide Post-Translational Modifications and Database Search Algorithms for Characterization of Intact <i>H. </i><i>p</i><i>ylori</i>

Abstract excerpt

MALDI-TOF mass spectrometry has been coupled with Internet-based proteome database search algorithms in an approach for direct microorganism identification. This approach is applied here to characterize intact H. pylori (strain 26695) Gram-negative bacteria, the most ubiquitous human pathogen. A procedure for including a specific and common posttranslational modification, N-terminal Met cleavage, in the search...

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