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Article

Efficient in vivo gene expression by trans-splicing adeno-associated viral vectors.

Nature biotechnology - 1 Nov 2005

Lai Yi, Yue Yongping, Liu Mingju, Ghosh Arkasubhra, Engelhardt John F, Chamberlain Jeffrey S, Duan Dongsheng

Abstract excerpt

Although adeno-associated virus (AAV)-mediated gene therapy has been hindered by the small viral packaging capacity of the vector, trans-splicing AAV vectors are able to package twice the size of the vector genome. Unfortunately, the efficiency of current trans-splicing vectors is very low. Here...

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Identifiers

PMID: 16244658
DOI: 10.1038/nbt1153
PMCID: PMC2581721

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16244658-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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