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Article

Insufficient adrenarche in patients with combined pituitary hormone deficiency caused by a PROP-1 gene defect.

Journal of pediatric endocrinology & metabolism : JPEM - 1 Jan 2000

Voutetakis A, Livadas S, Sertedaki A, Maniati-Christidi M, Dacou-Voutetakis C

Abstract excerpt

Adrenarche was evaluated in five patients, aged 17.4 +/- 3 years, with combined pituitary hormone deficiency (CPHD), caused by a PROP-1 gene defect. Adrenocorticotrophic hormone (ACTH), cortisol and dehydroepiandrosterone sulfate (DHEAS) were determined prior to and following the administration of corticotropin-releasing hormone (CRH) in four of the five patients, while only basal values of ACTH, cortisol and...

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Source

Identifiers

PMID: 11592567
DOI: 10.1515/jpem-2001-0806

Genes

CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Insufficient adrenarche in patients with combined pituitary hormone deficiency caused by a PROP-1 gene defect.PMID 11592567Read ↗

Adrenocorticotropin deficiency in combined pituitary hormone deficiency patients homozygous for a novel PROP1 deletion.Semantic proximity Read ↗

Central hypocortisolism as part of combined pituitary hormone deficiency due to mutations of PROP-1 gene.Semantic proximity Read ↗

PROP1 mutations cause progressive deterioration of anterior pituitary function including adrenal insufficiency: a longitudinal analysis.Semantic proximity Read ↗

Longitudinal imaging reveals pituitary enlargement preceding hypoplasia in two brothers with combined pituitary hormone deficiency attributable to PROP1 mutation.Semantic proximity Read ↗

Autosomal recessive deficiency of combined pituitary hormones (except ACTH) in a consanguineous Brazilian kindred.Semantic proximity Read ↗

Combined pituitary hormone deficiency in an inbred Brazilian kindred associated with a mutation in the PROP-1 gene.Semantic proximity Read ↗

PROP-1 gene mutation (R120C) causing combined pituitary hormone deficiencies with variable clinical course in eight siblings of one Jewish Moroccan family.Semantic proximity Read ↗

Familial combined pituitary hormone deficiency caused by PROP-1 gene mutation. Growth patterns and MRI studies in untreated subjects.Semantic proximity Read ↗

Aged PROP1 deficient dwarf mice maintain ACTH production.Semantic proximity Read ↗

Diminished adrenal androgen secretion in familial glucocorticoid deficiency implicates a significant role for ACTH in the induction of adrenarche.Semantic proximity Read ↗

ACTH: cellular peptide hormone synthesis and secretory pathways.Semantic proximity Read ↗

Combined pituitary hormone deficiency and PROP-1 mutation in two siblings: a distinct MR imaging pattern of pituitary enlargement.Semantic proximity Read ↗

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