Article
Combined pituitary hormone deficiency and PROP-1 mutation in two siblings: a distinct MR imaging pattern of pituitary enlargement.
AJNR. American journal of neuroradiology - 1 Aug 2007
do Amaral L L F, Ferreira R M, Ferreira N P F D, Mendonça R A, Marussi V H R, da Cunha J L, Maçaranduba B R, Medeiros J D
Abstract excerpt
Mutations of the PROP-1 gene are the most frequent genetic defect in patients with combined pituitary hormone insufficiency. We present the cases of 2 siblings with PROP-1 mutations whom we observed longitudinally. Their initial pituitary MR imaging examinations showed identical findings: an enlarged adenohypophysis, with striking hypointensity on T2-weighted images and slight hyperintensity on T1-weighted...
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