Article
Apolipoprotein E polymorphism and lithogenic factors in gallbladder bile.
European journal of clinical investigation - 1 Sept 2001
Fischer S, Dolu M H, Zündt B, Meyer G, Geisler S, Jüngst D
Abstract excerpt
BACKGROUND: Associations between the polymorphism of apolipoprotein E, which plays an important role in cholesterol metabolism and cholesterol gallstone formation, have been reported recently. Patients with the apo E4 isoform showed increased numbers and cholesterol contents of their stones, a higher frequency of cholesterol crystals in bile, increased susceptibility to gallstone fragmentation by extracorporeal...
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