Article
Reliability of preimplantation diagnosis for single gene disorders.
Molecular and cellular endocrinology - 22 Oct 2001
Rechitsky S, Verlinsky O, Amet T, Rechitsky M, Kouliev T, Strom C, Verlinsky Y
Abstract excerpt
Reliability of preimplantation genetic diagnosis (PGD) depends on controlling one of the most important limitations of single cell PCR, undetected allele drop out (ADO), which may lead to misdiagnosis. To avoid this we introduced mutation analysis simultaneously with linked polymorphic markers, pre-selecting only those embryos whose unaffected status could be confirmed by at least one linked polymorphic marker....
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