Article
The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E.
Journal of molecular biology - 28 Sept 2001
Kentsis A, Dwyer E C, Perez J M, Sharma M, Chen A, Pan Z Q, Borden K L
Abstract excerpt
The promyelocytic leukemia protein (PML) is a mammalian regulator of cell growth which is characteristically disrupted in acute promyelocytic leukemia and by a variety of viruses. PML contains a RING domain which is required for its growth-suppressive and antiviral properties. Although normally nuclear, in certain pathogenic conditions, including arenaviral infection, PML is relocated to the cytoplasm, where its...
Topics
- Arenavirus
- Binding Sites
- Circular Dichroism
- Eukaryotic Initiation Factor-4E
- Genes, Reporter
- HeLa Cells
- Humans
- Ligases
- Models, Molecular
- Mutation
- Neoplasm Proteins
- Nuclear Proteins
- Peptide Initiation Factors