Article
The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E.
Journal of molecular biology - 28 Sept 2001
Kentsis A, Dwyer E C, Perez J M, Sharma M, Chen A, Pan Z Q, Borden K L
Abstract excerpt
The promyelocytic leukemia protein (PML) is a mammalian regulator of cell growth which is characteristically disrupted in acute promyelocytic leukemia and by a variety of viruses. PML contains a RING domain which is required for its growth-suppressive and antiviral properties. Although normally nuclear, in certain pathogenic conditions, including arenaviral infection, PML is relocated to the cytoplasm, where its...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.