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Article

Detection of ciprofloxacin-resistant Yersinia pestis by fluorogenic PCR using the LightCycler.

Journal of clinical microbiology - 1 Oct 2001

Lindler L E, Fan W, Jahan N

Abstract excerpt

We have developed a fluorescence resonance energy transfer (FRET)-based assay to detect ciprofloxacin resistant (Cp(r)) mutants of the biothreat agent Yersinia pestis. We selected spontaneous mutants of the attenuated Y. pestis KIM 5 strain that were resistant to a ciprofloxacin (CIP) concentration of at least 1 microg/ml. DNA sequencing of gyrA encoded by 65 of these mutants revealed that all isolates contained...

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Identifiers

PMID: 11574586
DOI: 10.1128/JCM.39.10.3649-3655.2001
PMCID: PMC88402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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