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Article

Detection and identification of ciprofloxacin-resistant Yersinia pestis by denaturing high-performance liquid chromatography.

Journal of clinical microbiology - 1 Jul 2003

Hurtle William, Lindler Luther, Fan Wei, Shoemaker David, Henchal Erik, Norwood David

Abstract excerpt

Denaturing high-performance liquid chromatography (DHPLC) has been used extensively to detect genetic variation. We used this method to detect and identify Yersinia pestis KIM5 ciprofloxacin-resistant isolates by analyzing the quinolone resistance-determining region (QRDR) of the gyrase A gene. Sequencing of the Y. pestis KIM5 strain gyrA QRDR from 55 ciprofloxacin-resistant isolates revealed five mutation types....

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Source

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Identifiers

PMID: 12843075
DOI: 10.1128/JCM.41.7.3273-3283.2003
PMCID: PMC165339

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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