Article
A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects.
Genome medicine - 8 Mar 2022
Acosta-Uribe Juliana, Aguillón David, Cochran J Nicholas, Giraldo Margarita, Madrigal Lucía, Killingsworth Bradley W, Singhal Rijul, Labib Sarah, Alzate Diana, Velilla Lina, Moreno Sonia, García Gloria P, Saldarriaga Amanda, Piedrahita Francisco, Hincapié Liliana, López Hugo E, Perumal Nithesh, Morelo Leonilde, Vallejo Dionis, Solano Juan Marcos, Reiman Eric M, Surace Ezequiel I, Itzcovich Tatiana, Allegri Ricardo, Sánchez-Valle Raquel, Villegas-Lanau Andrés, White Charles L, Matallana Diana, Myers Richard M, Browning Sharon R, Lopera Francisco, Kosik Kenneth S
Abstract excerpt
BACKGROUND: The Colombian population, as well as those in other Latin American regions, arose from a recent tri-continental admixture among Native Americans, Spanish invaders, and enslaved Africans, all of whom passed through a population bottleneck due to widespread infectious diseases that left small isolated local settlements. As a result, the current population reflects multiple founder effects derived from...
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