Article
Evidence That Human Epididymal Protein ARP Plays a Role in Gamete Fusion Through Complementary Sites on the Surface of the Human Egg1
1 Oct 2001
Abstract excerpt
Human epididymal sperm protein ARP, a member of the cysteine-rich secretory proteins (CRISP) family, exhibits significant homology with rat epididymal protein DE, a candidate molecule for mediating sperm-egg fusion in rodents. The aim of this study was to investigate the involvement of ARP in human gamete fusion. Sequential extraction of proteins from ejaculated human sperm revealed the existence of a population...
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