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Human fertilization: epididymal hCRISP1 mediates sperm-zona pellucida binding through its interaction with ZP3

12 Dec 2013

Abstract excerpt

Human epididymal CRISP1 (hCRISP1) associates with sperm during maturation and participates in gamete fusion through egg complementary sites. Its homology with both rodent epididymal CRISP1 and CRISP4 reported to participate in the previous stage of sperm binding to the zona pellucida (ZP), led us to further investigate the functional role of hCRISP1 by studying its involvement in human sperm-ZP interaction. Human...

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PMID: 24334245
DOI: 10.1093/molehr/gat092

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