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Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

27 Jul 2016

Abstract excerpt

BACKGROUND: Cellular senescence is induced either internally, for example by replication exhaustion and cell division, or externally, for example by irradiation. In both cases, cellular damages accumulate which, if not successfully repaired, can result in senescence induction. Recently, we determined the transcriptional changes combined with the transition into replicative senescence in primary human fibroblast...

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PMID: 27464526
DOI: 10.1186/s40659-016-0095-2

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