Article
Induction of a dopaminergic phenotype in cultured striatal neurons by bone morphogenetic proteins.
Brain research. Developmental brain research - 23 Sept 2001
Stull N D, Jung J W, Iacovitti L
Abstract excerpt
In the present study, we examined whether the bone morphogenetic proteins (BMPs), which are important in the developmental specification of transmitter type in certain classes of neurons, might also play a role in signaling the differentiation of a dopaminergic (DA) phenotype. We found that BMP-2, -4 and -6 were each capable of inducing, in a dose and time dependent manner, moderate levels of the DA enzyme...
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