Developmental expression of cytochrome P450 aromatase genes (CYP19a and CYP19b) in zebrafish fry (<i>Danio rerio</i>)

Abstract excerpt

Cytochrome P450 aromatase (CYP19) is the terminal enzyme in the steroidogenic pathway that converts androgens (e.g., testosterone) into estrogens (e.g., estradiol). Regulation of this gene dictates the ratio of androgens to estrogens; therefore, appropriate expression of this enzyme is critical for reproduction as well as being pivotal in sex differentiation for most vertebrates. It is assumed that most...

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