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Article

Protection Against Autoimmune Myocarditis by Gene Transfer of Interleukin-10 by Electroporation

4 Sept 2001

Abstract excerpt

BACKGROUND: Although immunosuppressive therapy for myocarditis has attracted a great deal of attention, its effectiveness is controversial. Interleukin (IL)-10 has a variety of immunomodulatory properties. Among the nonviral techniques for gene transfer in vivo, the direct injection of plasmid DNA into muscle is simple, inexpensive, and safe. METHODS AND RESULTS: We examined the applicability of murine IL-10...

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PMID: 11535562
DOI: 10.1161/hc3501.096190

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