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Article

Intramyocardial Gene Therapy with Naked DNA Encoding Vascular Endothelial Growth Factor Improves Collateral Flow to Ischemic Myocardium

10 Dec 1999

Abstract excerpt

Both VEGF protein and VEGF DNA in combination with an adenoviral vector have been shown to enhance collateral formation in a porcine model of chronic myocardial ischemia. We sought to determine whether direct intramyocardial injection of naked DNA encoding for VEGF could similarly improve myocardial perfusion. Initially, 23 nonischemic pigs received either 200 microg of plasmid DNA encoding beta-galactosidase...

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Cardiac Valve Diseases and Treatments
Congenital heart defects research
Transplantation: Methods and Outcomes

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PMID: 10609656
DOI: 10.1089/10430349950016366

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Intramyocardial Gene Therapy with Naked DNA Encoding Vascular Endothelial Growth Factor Improves Collateral Flow to Ischemic MyocardiumPMID 10609656Read ↗

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