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Article

AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid

29 Nov 2007

Abstract excerpt

Adeno-associated virus (AAV) has many properties of an ideal vector for delivery of therapeutic genes into the myocardium. Previous studies in a mouse model of myocardial infarction showed that AAV serotype 1 (AAV1) is superior to AAV serotypes 2-5 to transfer genes into the myocardium by direct injection. Since vectors may behave differently in humans and because the human and the pig hearts resemble each other...

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PMID: 18044793
DOI: 10.1002/jgm.1129

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