Resveratrol, a tumor‐suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl‐2

Abstract excerpt

ABSTRACT We report that resveratrol (3,5,4′‐trihydroxy‐ trans ‐stilbene), a phytoalexin found in grapes and other plant food, induced a breakdown of the mitochondrial transmembrane potential (∆Ψ m ) in T‐acute lymphoblastic leukemia cells and swelling of isolated rat mitochondria. The breakdown of ∆Ψm was accompanied by the production of reactive oxygen species (ROS), and preceded phosphatidylserine exposure and...

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