Article
Delta regulates keratinocyte spreading and motility independently of differentiation.
Mechanisms of development - 1 Sept 2001
Lowell S, Watt F M
Abstract excerpt
In human interfollicular epidermis stem cells lie in clusters surrounded by their differentiated daughters, transit amplifying cells, an arrangement that reflects differences in cell cohesiveness and motility. Keratinocytes expressing a dominant negative Delta1 mutant, Delta(T), lacking most of the cytoplasmic domain, acquired the motile behaviour of transit cells while retaining their stem cell identity....
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