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Is the decline of desert bighorn sheep from infectious disease the result of low MHC variation?

Heredity - 1 Apr 2001

Gutierrez-Espeleta G A, Hedrick P W, Kalinowski S T, Garrigan D, Boyce W M

Abstract excerpt

Bighorn sheep populations have greatly declined in numbers and distribution since European settlement, primarily because of high susceptibility to infectious diseases transmitted to them from domestic livestock. It has been suggested that low variation at major histocompatibility complex (MHC) genes, the most important genetic aspect of the vertebrate immune system, may result in high susceptibility to infectious...

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Identifiers

PMID: 11520344
DOI: 10.1046/j.1365-2540.2001.00853.x

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Source receipt: pubmed, retrieved 7 Sept 2026.

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