Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.

doi:10.1186/s12864-024-10053-3

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Article

Exploring genetic diversity and variation of Ovar-DRB1 gene in Sudan Desert Sheep using targeted next-generation sequencing.

BMC genomics - 8 Feb 2024

Salim Bashir, Nakao Ryo, Chatanga Elisha, Marcuzzi Olivia, Eissawi Muna Ahmed, Almathen Faisal, Hanotte Olivier, Giovambattista Guillermo

Abstract excerpt

INTRODUCTION: The Ovar-DRB1 gene, a crucial element of the Major Histocompatibility Complex (MHC) Class II region, initiates adaptive immunity by presenting antigens to T-cells. Genetic diversity in sheep, particularly in MHC Class II genes like Ovar-DRB1, directly influences the specturm of presented antigens impacting immune responses and disease susceptability. Understanding the allelic diversity of Ovar-DRB1...

Topics

Sheep
Animals
Genetic Variation
Disease Resistance
Sudan
Histocompatibility Antigens Class II
Alleles
High-Throughput Nucleotide Sequencing

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PMID: 38331741
DOI: 10.1186/s12864-024-10053-3
PMCID: PMC10851530

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