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Effects of Blood-Processing Protocols on Fetal and Total DNA Quantification in Maternal Plasma

1 Sept 2001

Abstract excerpt

BACKGROUND: Recently, apoptotic cells have been found in plasma obtained by centrifugation of blood from pregnant women, raising the question of what constitutes plasma and whether plasma is truly cell free. We compared the effects of different blood-processing protocols on the quantification, DNA composition, and day-to-day fluctuation of fetal and total DNA in maternal plasma. METHODS: Blood samples were...

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PMID: 11514393
DOI: 10.1093/clinchem/47.9.1607

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