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Article

Absence of association between cyclin D1 (CCND1) G870A polymorphism and age of onset in hereditary nonpolyposis colorectal cancer.

Cancer letters - 18 May 2006

Krüger Stefan, Engel Christoph, Bier Andrea, Mangold Elisabeth, Pagenstecher Constanze, Doeberitz Magnus von Knebel, Holinski-Feder Elke, Moeslein Gabriela, Keller Gisela, Kunstmann Erdmute, Friedl Waltraut, Plaschke Jens, Rüschoff Josef, Schackert Hans K

Abstract excerpt

CCND1 encodes cyclin D1, which plays an important role in the G1 to S phase transition of the cell cycle. A common polymorphism (c.G870A) increases alternate splicing. Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by mutations in mismatch repair (MMR) genes, mainly MSH2 and MLH1, and shows a wide range in the age of its onset (AO), suggesting the existence of other modifying genetic factors. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

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Source

Identifiers

PMID: 16832876
DOI: 10.1016/j.canlet.2005.05.013

Genes

CCND1
MLH1
MSH2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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