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Article

Relative frequency and morphology of cancers in carriers of germline TP53 mutations.

Oncogene - 2 Aug 2001

Birch J M, Alston R D, McNally R J, Evans D G, Kelsey A M, Harris M, Eden O B, Varley J M

Abstract excerpt

The spectrum and frequency of cancers associated with germline TP53 mutations are uncertain. To address this issue a cohort of individuals from 28 families with Li-Fraumeni syndrome, segregating germline TP53 mutations was established. Predicted cancers were estimated by applying age, morphology, site and sex-specific UK cancer statistics to person-years at risk. Observed and predicted cancers were compared and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11498785
DOI: 10.1038/sj.onc.1204621

Genes

TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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