Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mechanism of growth-inhibitory effect of cisplatin on human pancreatic cancer cells and status of p53 gene.

Anticancer research - 1 Jan 2000

Seki T, Ohba N, Makino R, Funatomi H, Mitamura K

Abstract excerpt

Pancreatic cancer is a devastating malignant tumor in humans and the development of new modalities of treatment is needed. We studied the mechanism of the growth-inhibitory effect of cisplatin (CDDP) on human pancreatic cancer cells in connection with the status of the p53 gene and expression of the bcl-2 family. COLO-357 cells with wild-type p53 gene and T3M4, Panc-1 and AsPC-1 cells with mutant-p53 gene were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to bcl-2-Associated X Protein
Share to bcl-X Protein
Share to Cisplatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Culture Media, Serum-Free

Share to DNA Fragmentation

Share to Enzyme-Linked Immunosorbent Assay

Share to Pancreatic Neoplasms

Share to Proto-Oncogene Proteins c-bcl-2

Source

Identifiers

PMID: 11497278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mechanism of growth-inhibitory effect of cisplatin on human pancreatic cancer cells and status of p53 gene.PMID 11497278Read ↗

An exogenous cdk inhibitor, butyrolactone-I, induces apoptosis with increased Bax/Bcl-2 ratio in p53-mutated pancreatic cancer cells.Semantic proximity Read ↗

p53 restoration can overcome cisplatin resistance through inhibition of Akt as well as induction of Bax.Semantic proximity Read ↗

Apoptosis and Expression of the Bcl-2 Family of Proteins and P53 in Human Pancreatic Ductal AdenocarcinomaSemantic proximity Read ↗

Role of Bcl-2 family proteins (Bax, Bcl-2 and Bcl-X) on cellular susceptibility to radiation in pancreatic cancer cells.Semantic proximity Read ↗

Inhibiting effect of murine double minute-2 oncogene on apoptosis induced by retroviral-mediated wild-type p53.Semantic proximity Read ↗

Mesothelin regulates growth and apoptosis in pancreatic cancer cells through p53-dependent and -independent signal pathway.Semantic proximity Read ↗

p53 gene status and chemosensitivity in ovarian cancer.Semantic proximity Read ↗

Bcl-2 expression related to altered p53 protein and its impact on the progression of human pancreatic carcinoma.Semantic proximity Read ↗

Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity.Semantic proximity Read ↗

Molecular effects of taxol and caffeine on pancreatic cancer cells.Semantic proximity Read ↗

The effect of wild type P53 gene transfer on growth properties and tumorigenicity of PANC-1 tumor cell line.Semantic proximity Read ↗

[Effects of wild-type p53 gene on the chemotherapy sensitivity of ovarian cancer SKOV-3 cells to cisplatin].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.