Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at <i>MLL</i> and <i>AF-4</i> genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation

Abstract excerpt

We analyzed the der(11) and der(4) genomic breakpoint junctions of a t(4;11) in the leukemia of a patient previously administered etoposide and dactinomycin by molecular and biochemical approaches to gain insights about the translocation mechanism and the relevant drug exposure. The genomic breakpoint junctions were amplified by PCR. Cleavage of DNA substrates containing the normal homologues of the MLL and AF-4...

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