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Article

Pharmacokinetic studies of Gln117 tissue-type plasminogen activator in rats.

Journal of pharmaceutical and biomedical analysis - 1 Oct 2001

Aoki S, Kitagawa M, Okumura K

Abstract excerpt

Gln117 t-PA is a mutant type of tissue-type plasminogen activator (mt-PA), which is generated by the removal of a high mannose oligosaccharide resulting from the mutation of amino acid #117, from asparagine (Asn) to glutamine (Gln). The plasma concentration, distribution, metabolism and excretion of Gln117 t-PA were investigated after a single intravenous administration of 125I-Gln117 t-PA or Gln117 t-PA,...

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Identifiers

PMID: 11489391
DOI: 10.1016/s0731-7085(01)00431-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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