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Article

Specific Evolution and Gene Family Expansion of Complement 3 and Regulatory Factor H in Fish

14 Dec 2020

Abstract excerpt

The complement system comprises a large family of plasma proteins that play a central role in innate and adaptive immunity. To better understand the evolution of the complement system in vertebrates and the contribution of complement to fish immunity comprehensivein silicoand expression analysis of the gene repertoire was made. Particular attention was given to C3 and the evolutionary related proteins C4 and C5...

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PMID: 33381109
DOI: 10.3389/fimmu.2020.568631

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