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Article

Mutation in Serratia marcescens AmpC beta-lactamase producing high-level resistance to ceftazidime and cefpirome.

Antimicrobial agents and chemotherapy - 1 Aug 2001

Raimondi A, Sisto F, Nikaido H

Abstract excerpt

Starting from a clinical isolate of Serratia marcescens that produced a chromosomally encoded AmpC beta-lactamase inducibly, we isolated by stepwise selection two laboratory mutants that showed high levels of resistance to some cephalosporins. The 98R mutant apparently overproduced the unaltered beta-lactamase constitutively, but the 520R mutant produced an altered enzyme, also constitutively. Ceftazidime and...

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Identifiers

PMID: 11451693
DOI: 10.1128/AAC.45.8.2331-2339.2001
PMCID: PMC90650

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