Article
Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jul 2001
Hanazawa M, Mochii M, Ueno N, Kohara Y, Iino Y
Abstract excerpt
Caenorhabditis elegans is an ideal organism for the study of the molecular basis of fundamental biological processes such as germ-line development, especially because of availability of the whole genome sequence and applicability of the RNA interference (RNAi) technique. To identify genes involved in germ-line development, we produced subtracted cDNA pools either enriched for or deprived of the cDNAs from...
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