Article
MAO-A and COMT polymorphisms and gene effects in narcolepsy.
Molecular psychiatry - 1 Jul 2001
Dauvilliers Y, Neidhart E, Lecendreux M, Billiard M, Tafti M
Abstract excerpt
Narcolepsy presents one of the tightest associations with a specific HLA antigen (DQB1*0602) but there is strong evidence that non-HLA genes also confer susceptibility. Recent observations have implicated the hypocretin/orexin system in narcolepsy in both humans and animals. In addition, the implication of monoaminergic systems in the pathophysiology of narcolepsy is well established and a significant association...
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