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Article

Mechanisms of resistance against PKC412 in resistant FLT3-ITD positive human acute myeloid leukemia cells.

Annals of hematology - 1 Jul 2010

Stölzel Friedrich, Steudel Christine, Oelschlägel Uta, Mohr Brigitte, Koch Sina, Ehninger Gerhard, Thiede Christian

Abstract excerpt

Treatment of acute myeloid leukemia (AML) remains challenging with many patients harboring unfavorable prognostic parameters such as FLT3 internal tandem duplication (FLT3-ITD) mutations leading to a constitutively activated FLT3-receptor tyrosine kinase (RTK). Activation of proteins by phosphorylation of tyrosine residues is a common mechanism in leukemia development. Therefore, specific tyrosine kinase...

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Source

Identifiers

PMID: 20119833
DOI: 10.1007/s00277-009-0889-1

Genes

FLT3
JAG1
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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