Article
Recipient HLA-DR3, tumour necrosis factor-alpha promoter allele-2 (tumour necrosis factor-2) and cytomegalovirus infection are interrelated risk factors for chronic rejection of liver grafts.
Journal of hepatology - 1 May 2001
Evans P C, Smith S, Hirschfield G, Rigopoulou E, Wreghitt T G, Wight D G, Taylor C J, Alexander G J
Abstract excerpt
BACKGROUND/AIMS: The tumour necrosis factor (TNF)-2 promoter allele, which elicits elevated expression of TNF-alpha, is in linkage disequilibrium with the extended haplotype HLA-A1-B8-DR3-DQ2. TNF-2 and HLA-DR3 have been implicated in renal and cardiac graft rejection and loss. Cytomegalovirus (CMV) infection has been associated with chronic allograft rejection. We examined the relationship between HLA-DR3,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.