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Article

Role of Melanin in Melanocyte Dysregulation of Reactive Oxygen Species

1 Jan 2013

Abstract excerpt

We have recently reported a potential alternative tumor suppressor function for p16 relating to its capacity to regulate oxidative stress and observed that oxidative dysregulation in p16-depleted cells was most profound in melanocytes, compared to keratinocytes or fibroblasts. Moreover, in the absence of p16 depletion or exogenous oxidative insult, melanocytes exhibited significantly higher basal levels of...

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PMID: 23555101
DOI: 10.1155/2013/908797

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