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Pheomelanin-induced oxidative stress: bright and dark chemistry bridging red hair phenotype and melanoma.

Pigment cell & melanoma research - 1 Sept 2014

Napolitano Alessandra, Panzella Lucia, Monfrecola Giuseppe, d'Ischia Marco

Abstract excerpt

The complex interplay of genetic and epigenetic factors linking sun exposure to melanoma in the red hair phenotype hinges on the peculiar physical and chemical properties of pheomelanins and the underlying biosynthetic pathway, which is switched on by the effects of inactivating polymorphisms in the melanocortin 1 receptor gene. In addition to the long recognized UV-dependent pathways of toxicity and cell damage,...

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Identifiers

PMID: 24814217
DOI: 10.1111/pcmr.12262

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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