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Article

Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation.

The EMBO journal - 2 Jul 2001

Bryant N J, James D E

Abstract excerpt

Sec1p-like/Munc-18 (SM) proteins bind to t-SNAREs and inhibit ternary complex formation. Paradoxically, the absence of SM proteins does not result in constitutive membrane fusion. Here, we show that in yeast cells lacking the SM protein Vps45p, the t-SNARE Tlg2p is down-regulated, to undetectable levels, by rapid proteasomal degradation. In the absence of Vps45p, Tlg2p can be stabilized through abolition of...

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Identifiers

PMID: 11432826
DOI: 10.1093/emboj/20.13.3380
PMCID: PMC125511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation.PMID 11432826Read ↗

Cellular levels of the syntaxin Tlg2p are regulated by a single mode of binding to Vps45p.Semantic proximity Read ↗

The Sec1/Munc18 protein Vps45 regulates cellular levels of its SNARE binding partners Tlg2 and Snc2 in Saccharomyces cerevisiae.Semantic proximity Read ↗

The N-terminal peptide of the syntaxin Tlg2p modulates binding of its closed conformation to Vps45p.Semantic proximity Read ↗

The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes.Semantic proximity Read ↗

Two syntaxin homologues in the TGN/endosomal system of yeast.Semantic proximity Read ↗

Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p.Semantic proximity Read ↗

A novel SNARE complex implicated in vesicle fusion with the endoplasmic reticulum.Semantic proximity Read ↗

Structure-based functional analysis reveals a role for the SM protein Sly1p in retrograde transport to the endoplasmic reticulum.Semantic proximity Read ↗

A role for Tlg1p in the transport of proteins within the Golgi apparatus of Saccharomyces cerevisiae.Semantic proximity Read ↗

Concerted auto-regulation in yeast endosomal t-SNAREs.Semantic proximity Read ↗

How Tlg2p/syntaxin 16 'snares’ Vps45Semantic proximity Read ↗

Mutations of the SM protein Sly1 resulting in bypass of GTPase requirement in vesicular transport are confined to a short helical region.Semantic proximity Read ↗

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