Article
Induction of the ubiquitin-proteasome pathway during the keratocyte transition to the repair fibroblast phenotype.
Investigative ophthalmology & visual science - 1 Jul 2001
Stramer B M, Cook J R, Fini M E, Taylor A, Obin M
Abstract excerpt
PURPOSE: To examine dynamics and function of the ubiquitin (Ub)-proteasome pathway (UPP) during corneal stromal cell acquisition of the repair fibroblast phenotype. METHODS: An established cell culture model was used in which freshly isolated rabbit corneal stromal cells acquire a repair fibroblast phenotype, thereby mimicking injury-induced stromal cell activation. RESULTS: Transition to the repair fibroblast...
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