Article
[The attachment manner of ubiquitin to proinflammatory molecule discoidin domain receptor 2].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology - 1 Aug 2015
Yu Jiangtian, Bu Xin, Zhao Hu, Li Xia, Su Jin
Abstract excerpt
OBJECTIVE: To understand which lysine (K) residue in ubiquitin (Ub) is used to form a poly-Ubs chain on discoidin domain receptor 2 (DDR2). METHODS: The constructs encoding human DDR2 and Cbl-b were transiently transfected into HEK293T cells together with the Ub mutants with lysine mutation at different sites, and the transfected cells were stimulated with collagens in order to induce the activation of DDR2....
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