Article
Spatial regulation of DELTA expression mediates NOTCH signalling for segmentation of Drosophila legs.
Mechanisms of development - 1 Jul 2001
Mishra A, Agrawal N, Banerjee S, Sardesai D, Dalal J S, Bhojwani J, Sinha P
Abstract excerpt
The Notch (N) signalling pathway is recruited for segregation of cell fates in a number of Drosophila tissue types. We show here that N dependent segmentation of Drosophila legs is regulated by a dynamic pattern of expression of its ligand, DELTA (DL). During third larval instar and early stages of pupation, high levels of DL expression is seen in stripes of cells in the leg imaginal discs which later form the...
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