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Article

Site-directed mutagenesis and structural interpretation of the nidogen binding site of the laminin gamma1 chain.

The EMBO journal - 1 Oct 1996

Pöschl E, Mayer U, Stetefeld J, Baumgartner R, Holak T A, Huber R, Timpl R

Abstract excerpt

A precise molecular map of the nidogen binding site of laminins was obtained by site-directed mutagenesis and structural analysis of the 56 residue LE module gamma1III4 of their gamma1 chain. This demonstrated the crucial importance of the sequence DPNAV (position 800-804) in the disulfide-bonded loop a, with major contributions made by all residues except P801. Different substitutions of these residues...

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Identifiers

PMID: 8895559
PMCID: PMC452258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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