Ultraviolet B-induced apoptosis of human skin fibroblasts involves activation of caspase-8 and -3 with increased expression of vimentin

Abstract excerpt

BACKGROUND: After irradiation with a high dose of ultraviolet B (UVB), cells undergo apoptosis. Caspase-8 and -3 are key mediators of apoptosis in many cells. Vimentin, an important cytoskeleton component, can be cleaved by caspase-3, -6, -7 and -8. Cell apoptosis is promoted via caspase-triggered proteolysis of vimentin. In this study, we explored the roles of caspase-8 and -3 and the changes in vimentin...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hair Growth and Disorders
• Share to Skin and Cellular Biology Research
• Share to Skin Protection and Aging