Regulation of aldose reductase gene expression in renal cortex and medulla of rats.

doi:10.1007/BF02369352

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Article

Regulation of aldose reductase gene expression in renal cortex and medulla of rats.

Diabetologia - 1 Jan 1995

Dorin R I, Shah V O, Kaplan D L, Vela B S, Zager P G

Abstract excerpt

A role for aldose reductase-mediated production of polyol in the aetiology of diabetic nephropathy has been supported by both animal and clinical studies. In the renal medulla, the rate of polyol production is influenced in part by regulated changes in the level of aldose reductase gene expressio...

Topics

Actins
Aldehyde Reductase
Animals
Blotting, Northern
Galactose
Gene Expression Regulation, Enzymologic
Imidazoles
Imidazolidines
Kidney Cortex
Kidney Medulla
Male
Phenotype
RNA, Messenger
Rats
Rats, Sprague-Dawley

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