Article
A targeted mouse Brca1 mutation removing the last BRCT repeat results in apoptosis and embryonic lethality at the headfold stage.
Oncogene - 3 May 2001
Hohenstein P, Kielman M F, Breukel C, Bennett L M, Wiseman R, Krimpenfort P, Cornelisse C, van Ommen G J, Devilee P, Fodde R
Abstract excerpt
A mouse model with a targeted mutation in the 3' end of the endogenous Brca1 gene, Brca1(1700T), was generated to compare the phenotypic consequences of truncated Brca1 proteins with other mutant Brca1 models reported in the literature to date. Mice heterozygous for the Brca1(1700T) mutation do not show any predisposition to tumorigenesis. Treatment of these mice with ionizing radiation or breeding with Apc,...
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