Article
Extreme geographical fixation of variation in the Plasmodium falciparum gamete surface protein gene Pfs48/45 compared with microsatellite loci.
Molecular and biochemical parasitology - 1 Jul 2001
Conway D J, Machado R L, Singh B, Dessert P, Mikes Z S, Povoa M M, Oduola A M, Roper C
Abstract excerpt
Comparing patterns of genetic variation at multiple loci in the genome of a species can potentially identify loci which are under selection. The large number of polymorphic microsatellites in the malaria parasite Plasmodium falciparum are available markers to screen for selectively important loci. The Pfs48/45 gene on Chromosome 13 encodes an antigenic protein located on the surface of parasite gametes, which is...
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